More businesses and motorists face months of disruption as further rail bridge works began this week.
The work is the latest stage in the electrification of the rail line through Chorley by Network Rail.
The company has announced a number of bridge closures - with Stump Lane, Chorley, the latest.
Just weeks ago the rail bridge at busy Harpers Lane reopened after six months work on the line. Shopkeepers said takings were down. Buses were re-routed, causing inconvenience for passengers.
Network Rail said the following closures were all advanced works for the electrification of the route, and are part of a wider £1bn investment to provide faster more frequent services across the north.
Stump Lane is expected to be closed until May 12. Other closures include: Chorley Road from January 26 to June 19; Rawlinson Lane, Heath Charnock from January 5 to May 22.
A Network Rail spokesperson said: “Electrification will provide faster and more frequent services, with more seats for passengers, and help support economic growth across the North West of England. As part of this important upgrade, we need to carry out work on a number of structures to create the extra clearance for new overhead power lines and road closures will often be necessary to do this.
“We have worked closely with local authorities to plan the work in a way that causes minimal disruption and have ensured that residents and local businesses have been kept informed.”
It said it had organised public information events.
Jeanette Nelson, manager of The Grange residential care home, Stump Lane, said there were alternative routes for access to and from the home, but that it would be an inconvenience to some of its residents.
“It will affect our service-users. Shopping-wise, they’ve got to go a long way round,” she said. “They go into Asda and into town, so they’ve got to pay extra to get into town.”
She added: “I think they (Network Rail) could have waited until after Christmas.”
Sikandar Hayat, of Stump Lane Stores, said yesterday: “Obviously we’re worried about that because people used to stop in he car and by cigs. It’s only the first day, but no doubt about it we’re worried about it.”