Road closures are still in place after a serious crash on Bury Lane, police said.
Two people - one in critical condition - have been taken to hospital after a crash involving a car and an HGV at the junction of Bury Lane and Chorley Road in Withnell at around 2pm today.
Firefighters at the scene had to cut one victim from the car before paramedics could treat their injuries.
North West Ambulance Service confirmed that while an air ambulance was called, both casualties were taken to hospital in road ambulances.
Police have warned motorists that the roads remain closed, and have asked "all motorists to avoid the area and use alternative routes where possible".