Emil Riis gave the Lilywhites an early lead but Keane Lewis-Potter equalised for Hull 10 minutes before half-time.
The Tigers went 2-1 up just past the hour when Richie Smallwood's shot got deflections off Alan Browne and Liam Lindsay.
Josh Magennis poked home Hull's third goal in the 85th minute, with substitute Andy Cannon making it 4-1 in stoppage-time.
Here are the PNE player ratings from the clash.
Josh Magennis poked home Hull's third goal in the 85th minute, with substitute Andy Cannon making it 4-1 in stoppage-time.
2 / 4